Supplementary Information for: Single-molecule kinetics and footprinting of DNA bis-intercalation: the paradigmatic case of Thiocoraline
نویسندگان
چکیده
J. Camunas-Soler, 2 M. Manosas, 2 S. Frutos, 2 J. Tulla-Puche, 2 F. Albericio, 2 and F. Ritort 2, ∗ Small Biosystems Lab, Departament de F́ısica Fonamental, Facultat de F́ısica, Universitat de Barcelona, Barcelona, Spain CIBER de Bioingenieŕıa, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Madrid, Spain Institute for Research in Biomedicine(IRB Barcelona), Barcelona Science Park, Baldiri Reixac 10-12,08028, Barcelona, Spain
منابع مشابه
Single-molecule kinetics and footprinting of DNA bis-intercalation: the paradigmatic case of Thiocoraline
DNA bis-intercalators are widely used in molecular biology with applications ranging from DNA imaging to anticancer pharmacology. Two fundamental aspects of these ligands are the lifetime of the bis-intercalated complexes and their sequence selectivity. Here, we perform single-molecule optical tweezers experiments with the peptide Thiocoraline showing, for the first time, that bis-intercalation...
متن کاملDNA Intercalators and Using Them as Anticancer Drugs
Many anticancer drugs in clinical use interact with DNA through intercalation, which is process that starts with the transfer of the intercalating molecule from an aqueous environment to the hydrophobic space between two adjacent DNA base pairs. In general, intercalatig agents are two types: monofunctional and bifunctional. Monofunctional intercalators contain one intercalating unit and Bifunct...
متن کاملDNA Intercalators and Using Them as Anticancer Drugs
Many anticancer drugs in clinical use interact with DNA through intercalation, which is process that starts with the transfer of the intercalating molecule from an aqueous environment to the hydrophobic space between two adjacent DNA base pairs. In general, intercalatig agents are two types: monofunctional and bifunctional. Monofunctional intercalators contain one intercalating unit and Bifunct...
متن کاملThe EMBL nucleotide sequence data library.
nogalamycin and the duplex sequence dTpA (Brown et al., 1984), where it has been suggested that the sugar group at each end of the drug molecule (Fig. 2) sterically blocks the free movement of the chromophore in and out of the intercalation site. The intercalation process in solution has been extensively studied most often with reference to random-sequence DNA, and rather more rarely with respe...
متن کاملSolution structure of a 2:1 complex of anticancer drug XR5944 with TFF1 estrogen response element: insights into DNA recognition by a bis-intercalator
XR5944, a deoxyribonucleic acid (DNA) bis-intercalator with potent anticancer activity, can bind the estrogen response element (ERE) sequence to inhibit estrogen receptor-α activities. This novel mechanism of action may be useful for overcoming drug resistance to currently available antiestrogen treatments, all of which target the hormone-receptor complex. Here we report the nuclear magnetic re...
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تاریخ انتشار 2015